Hematopathology 3rd Edition - Expert Guide to Blood Disorders (E-Book)

 Table of Contents:

• Contributors
• Preface
• Part I. Technical Aspects
• Chapter 1. Processing of the Lymph Node Biopsy Specimen
• ASSESSING AND PRIORITIZING FRESH TISSUE
• GROSS PROCESSING OF THE LYMPH NODE BIOPSY
• ROUTINE HISTOLOGIC, HISTOCHEMICAL, AND SPECIAL STAINS
• REPORTING THE LYMPH NODE BIOPSY
• Pearls and Pitfalls
• Chapter 2. Fine-Needle Aspiration of Lymph Nodes
• SPECIMEN COLLECTION AND PROCESSING
• ANCILLARY STUDIES
• NON-NEOPLASTIC ASPIRATES
• ASPIRATES OF LYMPHOID NEOPLASMS
• LIMITATIONS OF FINE-NEEDLE ASPIRATION
• ROLE OF CORE NEEDLE BIOPSY IN LYMPHOMA DIAGNOSIS
• Pearls and Pitfalls
• Chapter 3. Immunohistochemistry for the Hematopathology Laboratory
• INTRODUCTION
• BASIC IMMUNOHISTOCHEMISTRY
• ANTIGENS OF HEMATOPATHOLOGIC INTEREST
• BEYOND DIAGNOSTICS: THE EVOLVING ROLE OF IMMUNOHISTOCHEMISTRY
• IN SITU HYBRIDIZATION
• APPROACH TO USING IMMUNOHISTOCHEMISTRY
• Pearls and Pitfalls
• Chapter 4. Flow Cytometry
• GENERAL PRINCIPLES
• TECHNICAL CONSIDERATIONS
• MATURE B-CELL NEOPLASMS
• PLASMA CELL NEOPLASMS
• MATURE T-CELL NEOPLASMS
• NATURAL KILLER CELL NEOPLASMS
• FLOW CYTOMETRY IN DIAGNOSIS AND CLASSIFICATION OF ACUTE LEUKEMIA
• CHRONIC MYELOID NEOPLASMS
• Acknowledgements
• Pearls and Pitfalls
• Chapter 5. Molecular Pathology of Hematologic Neoplasms
• INTRODUCTION
• BIOLOGICAL AND TECHNOLOGIC ISSUES
• LYMPHOID NEOPLASMS
• MYELOID NEOPLASMS
• POTENTIAL PITFALLS OF MOLECULAR TESTING
• SUMMARY AND CONCLUSIONS
• Acknowledgments
• Pearls and Pitfalls
• Chapter 6. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them
• TYPES OF CHROMOSOMAL ABERRATIONS IN HEMATOLOGIC MALIGNANCIES
• CONVENTIONAL CYTOGENETIC METHODS
• MOLECULAR CYTOGENETIC METHODS
• CLINICAL RELEVANCE OF CHROMOSOMAL ABNORMALITIES IN HEMATOLOGIC MALIGNANCIES
• CONCLUSION
• Pearls and Pitfalls
• Acknowledgments
• Part II. Normal and Reactive Conditions of Hematopoietic Tissues
• Chapter 7. Normal Lymphoid Organs and Tissues
• NORMAL LYMPHOID TISSUES
• B-CELL AND T-CELL DIFFERENTIATION
• Acknowledgements
• Pearls and Pitfalls
• Chapter 8. Reactive Lymphadenopathies
• FOLLICULAR AND NODULAR PATTERNS
• PREDOMINANTLY SINUS PATTERN
• INTERFOLLICULAR OR MIXED PATTERNS
• DIFFUSE PATTERN
• Pearls and Pitfalls
• Chapter 9. The Normal Bone Marrow
• INTRODUCTION
• MEDICAL INDICATIONS FOR BONE MARROW EXAMINATION
• COMPONENTS OF A BONE MARROW EVALUATION
• COLLECTION OF BONE MARROW ASPIRATE AND CORE BIOPSY
• PROCESSING OF MARROW TREPHINE BIOPSY AND ASPIRATE
• BONE MARROW EVALUATION
• CYTOCHEMISTRY AND HISTOCHEMISTRY
• BONE MARROW EXAMINATION AND REPORTING
• CONCLUSION
• Acknowledgments
• Pearls and Pitfalls
• Chapter 10. Evaluation of Anemia, Leukopenia, and Thrombocytopenia
• EVALUATION OF ANEMIA
• EVALUATION OF LEUKOPENIA
• EVALUATION OF THROMBOCYTOPENIA
• EVALUATION OF SPECIFIC BONE MARROW FAILURE SYNDROMES
• Pearls and Pitfalls
• Chapter 11. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders
• REACTIVE NEUTROPHILIA
• REACTIVE LYMPHOCYTOSIS
• REACTIVE EOSINOPHILIA
• REACTIVE BASOPHILIA
• REACTIVE MONOCYTOSIS
• BONE MARROW IN INFECTIOUS DISORDERS
• BONE MARROW IN NON-INFECTIOUS SYSTEMIC AND INFLAMMATORY DISORDERS
• CONCLUSION
• Pearls and Pitfalls
• Part III. Lymphoid Neoplasms
• Chapter 12. Principles of Classification of Lymphoid Neoplasms
• INTRODUCTION
• HISTORICAL BACKGROUND
• THE ICC AND WHO 5TH ED. PROPOSALS: SIMILARITIES AND DIFFERENCES
• CONCLUSION
• Pearls and Pitfalls
• Section 1. MATURE B-CELL NEOPLASMS
• Chapter 13. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia
• CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA
• MONOCLONAL B-CELL LYMPHOCYTOSIS
• B-CELL PROLYMPHOCYTIC LEUKEMIA
• Pearls and Pitfalls
• Chapter 14. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
• DEFINITION OF THE DISEASE
• SYNONYMS AND RELATED TERMS
• EPIDEMIOLOGY
• CLINICAL FEATURES
• MORPHOLOGY
• IMMUNOPHENOTYPE
• MOLECULAR GENETIC FINDINGS
• POSTULATED NORMAL COUNTERPART AND PATHOGENESIS
• CLINICAL COURSE, TREATMENT, AND PROGNOSIS
• DIFFERENTIAL DIAGNOSIS
• Pearls and Pitfalls
• Chapter 15. Hairy Cell Leukemia
• DEFINITION OF DISEASE AND NOMENCLATURE
• EPIDEMIOLOGY
• ETIOLOGY
• CLINICAL FEATURES
• MORPHOLOGY
• PHENOTYPE
• GENETICS AND MOLECULAR FINDINGS
• POSTULATED CELL OF ORIGIN AND NORMAL COUNTERPART
• VARIANTS
• DIFFERENTIAL DIAGNOSIS
• CLINICAL COURSE AND TREATMENT
• PROGNOSTIC AND PREDICTIVE FACTORS
• Pearls and Pitfalls
• Chapter 16. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen
• DEFINITION
• SYNONYMS AND RELATED TERMS
• EPIDEMIOLOGY
• ETIOLOGY
• CLINICAL FEATURES
• MORPHOLOGY
• IMMUNOPHENOTYPE
• GENETICS
• OTHER SPLENIC B-CELL LYMPHOMAS
• Pearls and Pitfalls
• Chapter 17. Follicular Lymphoma
• Definition
• Epidemiology
• Clinical Features
• Morphologic Features
• Grading and Terminology
• Related B-Cell Lymphomas and Follicular Proliferations
• Immunophenotype
• Cytogenetic and Genetic Features
• Postulated Normal Counterpart and Pathogenesis
• Etiology
• Clinical Course
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 18. Extranodal Marginal Zone Lymphoma: MALT Lymphoma
• Definition
• Synonyms and Related Terms
• Epidemiology
• Etiology
• Histopathology of Acquired Malt
• Pathology of Malt Lymphoma
• Immunohistochemistry
• Genetic Features of Malt Lymphoma
• Postulated Cell of Origin
• Clinical Course
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 19. Primary Cutaneous B-Cell Lymphomas
• Historical Background
• Primary Cutaneous MARGINAL ZONE Lymphoproliferative Disorder
• Primary Cutaneous FOLLICLE CENTER Lymphoma
• Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
• Intravascular Large B-Cell Lymphoma
• B-Lymphoblastic Lymphoma
• Ebv-Positive Mucocutaneous Ulcer and Other Cutaneous Immunodeficiency-Associated B-Cell LymphOproliferative Disorders
• Pearls and Pitfalls
• Chapter 20. Nodal Marginal Zone Lymphoma
• Definition
• Epidemiology, Etiology, and Cofactors
• Clinical Features
• Morphology
• Immunophenotype
• Genetics and Molecular Findings
• Postulated Cell of Origin
• Clinical Course and Prognostic Factors
• PEDIATRIC-TYPE NODAL MARGINAL ZONE LYMPHOMA (PT-NMZL)
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 21. Mantle Cell Lymphoma
• DEFINITION
• EPIDEMIOLOGY
• CLINICAL MANIFESTATIONS
• MORPHOLOGY
• IMMUNOPHENOTYPE
• MANTLE CELL LYMPHOMA VARIANTS
• CYTOGENETIC FINDINGS
• MOLECULAR CHARACTERISTICS
• POSTULATED CELL OF ORIGIN
• MULTISTEP DEVELOPMENT OF MANTLE CELL LYMPHOMA
• Clinical Course
• PROGNOSTIC PARAMETERS
• THERAPY
• DIFFERENTIAL DIAGNOSIS
• Pearls and Pitfalls
• Chapter 22. Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas
• INTRODUCTION
• DEFINITIONS, SYNONYMS, AND TERMS
• DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED
• T-CELL/HISTIOCYTE–RICH LARGE B-CELL LYMPHOMA
• PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA
• INTRAVASCULAR LARGE B-CELL LYMPHOMA
• Pearls and Pitfalls
• Chapter 23. Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements
• Why These Four Entities in One Chapter? A Historical Perspective On the Development of Disease Concepts
• BURKITT LYMPHOMA
• LARGE/HIGH-GRADE B-CELL LYMPHOMA WITH 11Q ABERRATION
• DIFFUSE LARGE B-CELL LYMPHOMA/HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS
• PROVISIONAL ENTITY: HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL6 REARRANGEMENTS
• HIGH-GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED
• Pearls and Pitfalls
• Chapter 24. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
• Plasmablastic Lymphoma
• Alk-Positive Large B-Cell Lymphoma
• Pearls and Pitfalls
• Chapter 25. Plasma Cell Neoplasms
• Classification Of Plasma Cell Neoplasms
• Pathogenesis of Plasma Cell Neoplasms
• Multiple Myeloma
• Monoclonal Gammopathy Of Undetermined Significance
• Plasmacytoma
• Immunoglobulin Deposition Diseases
• Plasma Cell Neoplasms With Associated Paraneoplastic Syndrome
• Pearls and Pitfalls
• Chapter 26. Nodular Lymphocyte-Predominant B-Cell Lymphoma
• Definition
• SYNONYMS AND RELATED TERMS
• Historical Background
• Epidemiology
• Clinical Features
• Morphology
• Immunophenotype
• Genetics and Molecular Findings
• Relationship With Progressively Transformed Germinal Centers
• Transformation To Diffuse Large B-Cell Lymphoma
• Relationship With T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
• Other Differential Diagnoses
• Treatment
• Prognosis
• Conclusion
• Pearls and Pitfalls
• Chapter 27. Classic Hodgkin Lymphoma
• Definition
• Synonyms and Related Terms
• Epidemiology
• Etiology
• Clinical Features
• Morphology
• Immunophenotype
• Genetics and Molecular Findings
• Postulated Cell of Origin
• Clinical Course and Prognostic Factors
• Related Lesions and Differential Diagnoses
• Pearls and Pitfalls
• Chapter 28. Virally Associated B-Cell Lymphoproliferative Disease
• Ebv-Associated Lymphoproliferative Disorders
• HHV-8-Associated Lymphoproliferative Disorders
• Pearls and Pitfalls
• Section 2. MATURE T-CELL AND NK-CELL NEOPLASMS
• Chapter 29. Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders
• INTRODUCTION
• Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis
• Chronic Active Epstein-Barr Virus Disease
• Severe Mosquito Bite Allergy
• Hydroa Vacciniforme Lymphoproliferative Disorder
• Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood
• Extranodal NK/T-Cell Lymphoma, Nasal Type
• Extranasal NK/T-Cell Lymphoma
• Aggressive Nk-Cell Leukemia
• Primary Nodal Epstein-Barr Virus–Positive T/Nk-Cell Lymphoma
• Pearls and Pitfalls
• Chapter 30. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
• History and Classification
• Definitions
• Synonyms and Related Terms
• Etiology and Epidemiology
• Clinical Features
• Morphology
• Immunophenotype
• Genetics and Molecular Findings
• Postulated Cell of Origin and Pathogenesis
• Clinical Management and Prognosis
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 31. T-Cell Prolymphocytic Leukemia
• Definition
• Consensus Criteria For Diagnosis
• Epidemiology
• Clinical Features
• Morphology
• Immunophenotype
• Genetics and Molecular Findings
• Postulated Cell of Origin
• Clinical Course
• Treatment
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 32. Adult T-Cell Leukemia/Lymphoma
• Definition
• Epidemiology
• Clinical Features
• Morphology
• Immunophenotype
• Genetics, Molecular Findings, and Role of HTLV-1
• Postulated Normal Counterpart
• Clinical Course
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 33. Hepatosplenic T-Cell Lymphoma
• Definition
• Epidemiology
• Etiology
• Clinical Features
• Morphology
• Phenotype
• Cytogenetic and Molecular Findings
• Postulated Cell of Origin
• CLINICAL Course
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 34. Peripheral T-Cell Lymphoma, Not Otherwise Specified
• Definition
• SYNONYMS AND RELATED TERMS
• Epidemiology
• Clinical Features
• Morphology
• Immunophenotype
• Genetic and Molecular Characteristics
• Variants and Subgroups
• Extranodal Peripheral T-Cell Lymphoma, Not Otherwise Specified
• Prognosis and Predictive Features
• Primary Nodal Epstein-Barr Virus–Positive T/Natural Killer–Cell Lymphoma
• Diagnostic Approach To Peripheral T-Cell Lymphoma, Not Otherwise Specified And Differential Diagnoses
• Pearls and Pitfalls
• Chapter 35. Follicular Helper T-Cell Lymphoma
• Definition
• Synonyms and Related Terms
• Epidemiology
• Etiology
• Follicular Helper T Cells
• Clinical Features
• Morphology
• Immunophenotype
• Genetics
• Clinical Course and Prognosis
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 36. Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative
• Definition and Background
• Anaplastic Large Cell Lymphoma, Alk Positive
• Anaplastic Large Cell Lymphoma, Alk Negative
• Breast Implant–Associated Anaplastic Large Cell Lymphoma
• Differential Diagnosis of Anaplastic Large Cell Lymphoma
• Pearls and Pitfalls
• Chapter 37. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
• Enteropathy-Associated T-Cell Lymphoma
• Refractory Celiac Disease
• Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
• Intestinal T-Cell Lymphoma, Not Otherwise Specified
• Indolent Natural Killer–Cell and T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract
• Pearls and Pitfalls
• Chapter 38. Mycosis Fungoides and Sézary Syndrome
• Mycosis Fungoides
• Sézary Syndrome
• Pearls and Pitfalls
• Chapter 39. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
• Definition
• SYNONYMS AND RELATED TERMS
• Epidemiology
• Etiology
• Clinical Features
• Morphology
• Immunophenotype
• Genetics and Molecular Findings
• Postulated Cell of Origin
• Clinical Course
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 40. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes
• Introduction
• Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma
• Primary Cutaneous γδ T-Cell Lymphoma
• Subcutaneous Panniculitis-Like T-Cell Lymphoma
• Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder
• Primary Cutaneous Acral CD8-Positive T-Cell Lymphoproliferative Disorder
• Other Types of Cutaneous T-Cell Lymphoma
• Pearls and Pitfalls
• Section 3. PRECURSOR B-AND T-CELL NEOPLASMS
• Chapter 41. Precursor B-Cell and T-Cell Neoplasms
• Classification of Precursor Lymphoid Neoplasms
• B-Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
• T-Cell Lymphoblastic Lymphoma/Lymphoblastic Leukemia
• Conclusion
• Pearls and Pitfalls
• Chapter 42. Acute Leukemias of Ambiguous Lineage
• Definitions
• Synonyms and Related Terms
• Epidemiology
• Clinical Features
• Diagnostic Criteria and Lineage Assignment
• Genetic and Molecular Findings
• Clinical Course
• Lineage Switch
• Differential Diagnosis
• Pearls and Pitfalls
• Part IV. Myeloid, Histiocytic, and Related Proliferations
• Chapter 43. Principles of Classification of Myeloid Neoplasms
• Introduction
• Evaluation of Myeloid Neoplasms
• International Consensus Classification
• Conclusion
• Acknowledgment
• Chapter 44. The Myelodysplastic Syndromes
• Incidence
• Synonyms and Related Terms
• Clinical Features
• Laboratory Features
• Diagnosis
• Classification
• Differential Diagnosis
• Etiology and Pathogenesis
• Conclusion
• Pearls and Pitfalls
• Chapter 45. Myeloid and Hematologic Neoplasms With Germline Predisposition
• Definition and Introduction
• Synonyms and Related Terms
• Hematologic Neoplasms with Germline Predisposition Without A Constitutional Disorder Affecting Multiple Organ Systems
• Hematologic Neoplasms with Germline Predisposition Associated with A Constitutional Platelet Disorder
• Hematologic Neoplasms with Germline Predisposition Associated with A Constitutional Disorder Affecting Multiple Organ Systems
• Acute Lymphoblastic Leukemia with Germline Predisposition
• Pearls and Pitfalls
• Chapter 46. Acute Myeloid Leukemia
• SYNONYMS AND RELATED TERMS
• EPIDEMIOLOGY
• ETIOLOGY
• CLINICAL FEATURES
• MORPHOLOGY
• CYTOCHEMISTRY
• IMMUNOPHENOTYPE
• GENETICS
• PROGNOSIS
• ACUTE MYELOID LEUKEMIA DISEASE TYPES
• MYELOID PROLIFERATIONS OF DOWN SYNDROME
• MYELOID SARCOMA
• DIAGNOSTIC QUALIFIERS IN ACUTE MYELOID LEUKEMIA
• INTEGRATED APPROACH TO THE DIAGNOSIS OF ACUTE MYELOID LEUKEMIA
• Pearls and Pitfalls
• Chapter 47. Myeloproliferative Neoplasms
• Introduction
• Etiology and Pathogenesis
• Chronic Myeloid Leukemia (CML)
• Chronic Neutrophilic Leukemia (CNL)
• Classic Bcr::Abl1-Negative Myeloproliferative Neoplasms
• Essential Thrombocythemia (ET)
• Primary Myelofibrosis (PMF)
• Polycythemia Vera
• Chronic Eosinophilic Leukemia, Not Otherwise Specified (CEL, NOS)
• Myeloproliferative Neoplasms, Unclassifiable (MPN-U)
• Conclusion
• Acknowledgments
• Pearls and Pitfalls
• Chapter 48. Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions
• Introduction
• Chronic Myelomonocytic Leukemia (CMML)
• Clonal Cytopenia With Monocytosis of Undetermined Significance and Clonal Monocytosis of Undetermined Significance
• Atypical Chronic Myeloid Leukemia (aCML)
• Myelodysplastic/Myeloproliferative Neoplasm With Sf3b1 Mutation and Thrombocytosis (MDS/MPN-SF3B1-T)
• Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified (MDS/MPN-RS-T, NOS)
• Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified (MDS/MPN, NOS)
• Myelodysplastic/Myeloproliferative Neoplasm With Isolated Isochromosome (17q) (MDS/MPM With i[17q]; ICC Provisional Subentity)
• Acknowledgments
• Pearls and Pitfalls
• Chapter 49. Mastocytosis
• Definition
• Synonyms and Related Terms
• General Aspects
• Epidemiology and Etiology
• Postulated Cell of Origin and Normal Counterpart
• Genetics and Molecular Findings
• Cytologic and Histologic Diagnosis
• Differential Diagnosis
• Classification
• Pearls and Pitfalls
• Chapter 50. Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions
• Overview
• Introduction
• Classification
• Clinical Presentation
• Approach To Diagnosis
• Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangements Of PDGFRA, PDGFRB, FGFR1, FLT3, OR JAK2 or with ETV6::ABL1
• CEL, NOS, IHE/IHES, and other Rare Reported Genetic Alterations Associated with Clonal Eosinophilia
• Conclusion
• Acknowledgments
• Pearls and Pitfalls
• Chapter 51. Blastic Plasmacytoid Dendritic Cell Neoplasm
• Definition
• Synonyms and Related Terms
• Epidemiology
• Etiology
• Clinical Features
• Morphology
• Immunophenotype
• Cytochemistry
• Genetics and Molecular Findings
• Postulated Cell of Origin and Normal Counterpart
• Clinical Course and Prognosis
• Differential Diagnosis
• Pearls and Pitfalls
• Chapter 52. Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic
• Non-Neoplastic Histiocytic Disorders
• Histiocytic and Dendritic Cell Neoplasms
• Acknowledgment
• Pearls and Pitfalls
• Part V. Immunodeficiency Disorders
• Chapter 53. The Pathology of Primary Immunodeficiencies
• Classification
• Synonyms and Related Terms
• Epidemiology
• Severe Combined Immunodeficiency
• PI3K-Related Immunodeficiencies
• Defects that Affect Homeostasis of The Immune System
• Defects in Synapse Formation and Crosstalk Between Antigen-Presenting Cells and T Cells
• Pearls and Pitfalls
• Chapter 54. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
• Definition
• Synonyms and Related Terms
• Classification
• Posttransplant Lymphoproliferative Disorders
• Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders in Nontransplant Settings
• Pearls and Pitfalls
• Part VI. Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia
• Chapter 55. Bone Marrow Evaluation for Lymphoma
• Distinction Between Benign Lymphoid Aggregates and Lymphoma
• Non-Hodgkin Lymphoma Involving Bone Marrow
• B-Cell Lymphomas Involving Bone Marrow
• T-Cell Lymphomas Involving Bone Marrow
• Hodgkin Lymphoma Involving Bone Marrow
• Nonlymphoid Malignancies That Mimic Lymphomas
• Pearls and Pitfalls
• Chapter 56. Evaluation of the Bone Marrow After Therapy
• Effects of Selected Therapies and Bone Marrow Transplantation
• Acute Leukemia or Myelodysplastic Syndrome
• Chronic Myeloid Leukemia
• BCR::ABL1-Negative Myeloproliferative Neoplasms
• Chronic Lymphoproliferative and Plasma Cell Disorders
• Other Bone Marrow Changes after Therapy
• Pearls and Pitfalls
• Chapter 57. Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes
• Introduction
• Metastatic Tumors of the Bone Marrow
• Primary Tumors of Bone
• Vascular Tumors Involving Bone
• Other Soft-Tissue Tumors Involving Bone
• Malignant Lymphomas Involving Bone and Bone Marrow
• Benign Lesions of Bone
• Metastatic Tumors to Lymph Nodes
• Benign Lymph Node Inclusions
• Mesenchymal Proliferations in Lymph Nodes
• Conclusion
• Pearls and Pitfalls
• Chapter 58. Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions
• The Normal Spleen
• Gross Examination
• Lymphoid Hyperplasia
• Castleman Disease
• Autoimmune Lymphoproliferative Syndrome
• Hodgkin Lymphoma
• Non-Hodgkin Lymphomas
• Precursor Lymphoid Neoplasms
• Systemic or Secondary Mature B-Cell Lymphomas and Leukemias
• Primary B-Cell Lymphoid Neoplasms Presenting With Prominent Splenomegaly
• Mature T-Cell and Natural Killer–Cell Neoplasms
• T-Cell Lymphoid Neoplasms Presenting With Prominent Splenomegaly
• Myeloid Neoplasms
• Systemic Mastocytosis
• Proliferations of the Monocyte-Macrophage System
• Mesenchymal Tumors and Non-Neoplastic Disorders That Mimic Neoplasms
• EPSTEIN-BARR VIRUS—POSITIVE INFLAMMATORY FOLLICULAR DENDRITIC CELL/FIBROBLASTIC RETICULAR CELL TUMOR AND REACTIVE PSEUDOTUMORAL LESIONS OF THE SPLEEN
• Splenic Cysts
• Other Tumors
• Storage Diseases
• Pearls and Pitfalls
• Chapter 59. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin
• Lymphomas of Immune-Privileged Sites
• Lymphoma of The Nervous System and Meninges
• Ocular Adnexal Lymphoma
• Lymphomas of Waldeyer’s Ring
• Lymphomas of The Nasal Cavity and Paranasal Sinuses
• Salivary Gland Lymphomas
• Lymphomas of The Oral Cavity
• Thyroid Lymphomas
• Laryngeal Lymphomas
• Pulmonary Lymphomas
• Lymphomas of The Pleura and Pleural Cavity
• Lymphomas of The Thymus
• Cardiac Lymphomas
• Lymphomas of The Breast
• Gastrointestinal Lymphomas
• Gastric Lymphoma
• Small and Large Intestinal Lymphomas
• Lymphomas of The Liver and Pancreatobiliary Tract
• Adrenal Lymphomas
• Urinary Tract Lymphomas
• Male Genital Tract Lymphomas
• Lymphomas of The Female Genital Tract
• Lymphomas of Bone
• Pearls and Pitfalls
• Appendix A. The International Consensus Classification of Myeloid, Lymphoid, and Histiocytic Neoplasms
• Index