Hematopathology 3rd Edition - Expert Guide to Blood Disorders (E-Book)

 

 Table of Contents:

  • Contributors
  • Preface
  • Part I. Technical Aspects
  • Chapter 1. Processing of the Lymph Node Biopsy Specimen
  • ASSESSING AND PRIORITIZING FRESH TISSUE
  • GROSS PROCESSING OF THE LYMPH NODE BIOPSY
  • ROUTINE HISTOLOGIC, HISTOCHEMICAL, AND SPECIAL STAINS
  • REPORTING THE LYMPH NODE BIOPSY
  • Pearls and Pitfalls
  • Chapter 2. Fine-Needle Aspiration of Lymph Nodes
  • SPECIMEN COLLECTION AND PROCESSING
  • ANCILLARY STUDIES
  • NON-NEOPLASTIC ASPIRATES
  • ASPIRATES OF LYMPHOID NEOPLASMS
  • LIMITATIONS OF FINE-NEEDLE ASPIRATION
  • ROLE OF CORE NEEDLE BIOPSY IN LYMPHOMA DIAGNOSIS
  • Pearls and Pitfalls
  • Chapter 3. Immunohistochemistry for the Hematopathology Laboratory
  • INTRODUCTION
  • BASIC IMMUNOHISTOCHEMISTRY
  • ANTIGENS OF HEMATOPATHOLOGIC INTEREST
  • BEYOND DIAGNOSTICS: THE EVOLVING ROLE OF IMMUNOHISTOCHEMISTRY
  • IN SITU HYBRIDIZATION
  • APPROACH TO USING IMMUNOHISTOCHEMISTRY
  • Pearls and Pitfalls
  • Chapter 4. Flow Cytometry
  • GENERAL PRINCIPLES
  • TECHNICAL CONSIDERATIONS
  • MATURE B-CELL NEOPLASMS
  • PLASMA CELL NEOPLASMS
  • MATURE T-CELL NEOPLASMS
  • NATURAL KILLER CELL NEOPLASMS
  • FLOW CYTOMETRY IN DIAGNOSIS AND CLASSIFICATION OF ACUTE LEUKEMIA
  • CHRONIC MYELOID NEOPLASMS
  • Acknowledgements
  • Pearls and Pitfalls
  • Chapter 5. Molecular Pathology of Hematologic Neoplasms
  • INTRODUCTION
  • BIOLOGICAL AND TECHNOLOGIC ISSUES
  • LYMPHOID NEOPLASMS
  • MYELOID NEOPLASMS
  • POTENTIAL PITFALLS OF MOLECULAR TESTING
  • SUMMARY AND CONCLUSIONS
  • Acknowledgments
  • Pearls and Pitfalls
  • Chapter 6. Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them
  • TYPES OF CHROMOSOMAL ABERRATIONS IN HEMATOLOGIC MALIGNANCIES
  • CONVENTIONAL CYTOGENETIC METHODS
  • MOLECULAR CYTOGENETIC METHODS
  • CLINICAL RELEVANCE OF CHROMOSOMAL ABNORMALITIES IN HEMATOLOGIC MALIGNANCIES
  • CONCLUSION
  • Pearls and Pitfalls
  • Acknowledgments
  • Part II. Normal and Reactive Conditions of Hematopoietic Tissues
  • Chapter 7. Normal Lymphoid Organs and Tissues
  • NORMAL LYMPHOID TISSUES
  • B-CELL AND T-CELL DIFFERENTIATION
  • Acknowledgements
  • Pearls and Pitfalls
  • Chapter 8. Reactive Lymphadenopathies
  • FOLLICULAR AND NODULAR PATTERNS
  • PREDOMINANTLY SINUS PATTERN
  • INTERFOLLICULAR OR MIXED PATTERNS
  • DIFFUSE PATTERN
  • Pearls and Pitfalls
  • Chapter 9. The Normal Bone Marrow
  • INTRODUCTION
  • MEDICAL INDICATIONS FOR BONE MARROW EXAMINATION
  • COMPONENTS OF A BONE MARROW EVALUATION
  • COLLECTION OF BONE MARROW ASPIRATE AND CORE BIOPSY
  • PROCESSING OF MARROW TREPHINE BIOPSY AND ASPIRATE
  • BONE MARROW EVALUATION
  • CYTOCHEMISTRY AND HISTOCHEMISTRY
  • BONE MARROW EXAMINATION AND REPORTING
  • CONCLUSION
  • Acknowledgments
  • Pearls and Pitfalls
  • Chapter 10. Evaluation of Anemia, Leukopenia, and Thrombocytopenia
  • EVALUATION OF ANEMIA
  • EVALUATION OF LEUKOPENIA
  • EVALUATION OF THROMBOCYTOPENIA
  • EVALUATION OF SPECIFIC BONE MARROW FAILURE SYNDROMES
  • Pearls and Pitfalls
  • Chapter 11. Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders
  • REACTIVE NEUTROPHILIA
  • REACTIVE LYMPHOCYTOSIS
  • REACTIVE EOSINOPHILIA
  • REACTIVE BASOPHILIA
  • REACTIVE MONOCYTOSIS
  • BONE MARROW IN INFECTIOUS DISORDERS
  • BONE MARROW IN NON-INFECTIOUS SYSTEMIC AND INFLAMMATORY DISORDERS
  • CONCLUSION
  • Pearls and Pitfalls
  • Part III. Lymphoid Neoplasms
  • Chapter 12. Principles of Classification of Lymphoid Neoplasms
  • INTRODUCTION
  • HISTORICAL BACKGROUND
  • THE ICC AND WHO 5TH ED. PROPOSALS: SIMILARITIES AND DIFFERENCES
  • CONCLUSION
  • Pearls and Pitfalls
  • Section 1. MATURE B-CELL NEOPLASMS
  • Chapter 13. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia
  • CHRONIC LYMPHOCYTIC LEUKEMIA/SMALL LYMPHOCYTIC LYMPHOMA
  • MONOCLONAL B-CELL LYMPHOCYTOSIS
  • B-CELL PROLYMPHOCYTIC LEUKEMIA
  • Pearls and Pitfalls
  • Chapter 14. Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
  • DEFINITION OF THE DISEASE
  • SYNONYMS AND RELATED TERMS
  • EPIDEMIOLOGY
  • CLINICAL FEATURES
  • MORPHOLOGY
  • IMMUNOPHENOTYPE
  • MOLECULAR GENETIC FINDINGS
  • POSTULATED NORMAL COUNTERPART AND PATHOGENESIS
  • CLINICAL COURSE, TREATMENT, AND PROGNOSIS
  • DIFFERENTIAL DIAGNOSIS
  • Pearls and Pitfalls
  • Chapter 15. Hairy Cell Leukemia
  • DEFINITION OF DISEASE AND NOMENCLATURE
  • EPIDEMIOLOGY
  • ETIOLOGY
  • CLINICAL FEATURES
  • MORPHOLOGY
  • PHENOTYPE
  • GENETICS AND MOLECULAR FINDINGS
  • POSTULATED CELL OF ORIGIN AND NORMAL COUNTERPART
  • VARIANTS
  • DIFFERENTIAL DIAGNOSIS
  • CLINICAL COURSE AND TREATMENT
  • PROGNOSTIC AND PREDICTIVE FACTORS
  • Pearls and Pitfalls
  • Chapter 16. Splenic Marginal Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen
  • DEFINITION
  • SYNONYMS AND RELATED TERMS
  • EPIDEMIOLOGY
  • ETIOLOGY
  • CLINICAL FEATURES
  • MORPHOLOGY
  • IMMUNOPHENOTYPE
  • GENETICS
  • OTHER SPLENIC B-CELL LYMPHOMAS
  • Pearls and Pitfalls
  • Chapter 17. Follicular Lymphoma
  • Definition
  • Epidemiology
  • Clinical Features
  • Morphologic Features
  • Grading and Terminology
  • Related B-Cell Lymphomas and Follicular Proliferations
  • Immunophenotype
  • Cytogenetic and Genetic Features
  • Postulated Normal Counterpart and Pathogenesis
  • Etiology
  • Clinical Course
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 18. Extranodal Marginal Zone Lymphoma: MALT Lymphoma
  • Definition
  • Synonyms and Related Terms
  • Epidemiology
  • Etiology
  • Histopathology of Acquired Malt
  • Pathology of Malt Lymphoma
  • Immunohistochemistry
  • Genetic Features of Malt Lymphoma
  • Postulated Cell of Origin
  • Clinical Course
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 19. Primary Cutaneous B-Cell Lymphomas
  • Historical Background
  • Primary Cutaneous MARGINAL ZONE Lymphoproliferative Disorder
  • Primary Cutaneous FOLLICLE CENTER Lymphoma
  • Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
  • Intravascular Large B-Cell Lymphoma
  • B-Lymphoblastic Lymphoma
  • Ebv-Positive Mucocutaneous Ulcer and Other Cutaneous Immunodeficiency-Associated B-Cell LymphOproliferative Disorders
  • Pearls and Pitfalls
  • Chapter 20. Nodal Marginal Zone Lymphoma
  • Definition
  • Epidemiology, Etiology, and Cofactors
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetics and Molecular Findings
  • Postulated Cell of Origin
  • Clinical Course and Prognostic Factors
  • PEDIATRIC-TYPE NODAL MARGINAL ZONE LYMPHOMA (PT-NMZL)
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 21. Mantle Cell Lymphoma
  • DEFINITION
  • EPIDEMIOLOGY
  • CLINICAL MANIFESTATIONS
  • MORPHOLOGY
  • IMMUNOPHENOTYPE
  • MANTLE CELL LYMPHOMA VARIANTS
  • CYTOGENETIC FINDINGS
  • MOLECULAR CHARACTERISTICS
  • POSTULATED CELL OF ORIGIN
  • MULTISTEP DEVELOPMENT OF MANTLE CELL LYMPHOMA
  • Clinical Course
  • PROGNOSTIC PARAMETERS
  • THERAPY
  • DIFFERENTIAL DIAGNOSIS
  • Pearls and Pitfalls
  • Chapter 22. Aggressive B-Cell Lymphomas Including Diffuse Large B-Cell Lymphoma, Not Otherwise Specified and Other Nodal and Extranodal Large B-Cell Lymphomas
  • INTRODUCTION
  • DEFINITIONS, SYNONYMS, AND TERMS
  • DIFFUSE LARGE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED
  • T-CELL/HISTIOCYTE–RICH LARGE B-CELL LYMPHOMA
  • PRIMARY MEDIASTINAL LARGE B-CELL LYMPHOMA
  • INTRAVASCULAR LARGE B-CELL LYMPHOMA
  • Pearls and Pitfalls
  • Chapter 23. Burkitt Lymphoma, High-Grade B-Cell Lymphoma Not Otherwise Specified, High-Grade B-Cell Lymphoma With MYC and BCL2/BCL6 Rearrangements, Large B-Cell Lymphoma With 11q Aberration, and Provisional Entity High-Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements
  • Why These Four Entities in One Chapter? A Historical Perspective On the Development of Disease Concepts
  • BURKITT LYMPHOMA
  • LARGE/HIGH-GRADE B-CELL LYMPHOMA WITH 11Q ABERRATION
  • DIFFUSE LARGE B-CELL LYMPHOMA/HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL2 REARRANGEMENTS
  • PROVISIONAL ENTITY: HIGH-GRADE B-CELL LYMPHOMA WITH MYC AND BCL6 REARRANGEMENTS
  • HIGH-GRADE B-CELL LYMPHOMA, NOT OTHERWISE SPECIFIED
  • Pearls and Pitfalls
  • Chapter 24. Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
  • Plasmablastic Lymphoma
  • Alk-Positive Large B-Cell Lymphoma
  • Pearls and Pitfalls
  • Chapter 25. Plasma Cell Neoplasms
  • Classification Of Plasma Cell Neoplasms
  • Pathogenesis of Plasma Cell Neoplasms
  • Multiple Myeloma
  • Monoclonal Gammopathy Of Undetermined Significance
  • Plasmacytoma
  • Immunoglobulin Deposition Diseases
  • Plasma Cell Neoplasms With Associated Paraneoplastic Syndrome
  • Pearls and Pitfalls
  • Chapter 26. Nodular Lymphocyte-Predominant B-Cell Lymphoma
  • Definition
  • SYNONYMS AND RELATED TERMS
  • Historical Background
  • Epidemiology
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetics and Molecular Findings
  • Relationship With Progressively Transformed Germinal Centers
  • Transformation To Diffuse Large B-Cell Lymphoma
  • Relationship With T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
  • Other Differential Diagnoses
  • Treatment
  • Prognosis
  • Conclusion
  • Pearls and Pitfalls
  • Chapter 27. Classic Hodgkin Lymphoma
  • Definition
  • Synonyms and Related Terms
  • Epidemiology
  • Etiology
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetics and Molecular Findings
  • Postulated Cell of Origin
  • Clinical Course and Prognostic Factors
  • Related Lesions and Differential Diagnoses
  • Pearls and Pitfalls
  • Chapter 28. Virally Associated B-Cell Lymphoproliferative Disease
  • Ebv-Associated Lymphoproliferative Disorders
  • HHV-8-Associated Lymphoproliferative Disorders
  • Pearls and Pitfalls
  • Section 2. MATURE T-CELL AND NK-CELL NEOPLASMS
  • Chapter 29. Epstein-Barr Virus–Associated T-Cell and Natural Killer–Cell Lymphoproliferative Disorders
  • INTRODUCTION
  • Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis
  • Chronic Active Epstein-Barr Virus Disease
  • Severe Mosquito Bite Allergy
  • Hydroa Vacciniforme Lymphoproliferative Disorder
  • Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma of Childhood
  • Extranodal NK/T-Cell Lymphoma, Nasal Type
  • Extranasal NK/T-Cell Lymphoma
  • Aggressive Nk-Cell Leukemia
  • Primary Nodal Epstein-Barr Virus–Positive T/Nk-Cell Lymphoma
  • Pearls and Pitfalls
  • Chapter 30. T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
  • History and Classification
  • Definitions
  • Synonyms and Related Terms
  • Etiology and Epidemiology
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetics and Molecular Findings
  • Postulated Cell of Origin and Pathogenesis
  • Clinical Management and Prognosis
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 31. T-Cell Prolymphocytic Leukemia
  • Definition
  • Consensus Criteria For Diagnosis
  • Epidemiology
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetics and Molecular Findings
  • Postulated Cell of Origin
  • Clinical Course
  • Treatment
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 32. Adult T-Cell Leukemia/Lymphoma
  • Definition
  • Epidemiology
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetics, Molecular Findings, and Role of HTLV-1
  • Postulated Normal Counterpart
  • Clinical Course
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 33. Hepatosplenic T-Cell Lymphoma
  • Definition
  • Epidemiology
  • Etiology
  • Clinical Features
  • Morphology
  • Phenotype
  • Cytogenetic and Molecular Findings
  • Postulated Cell of Origin
  • CLINICAL Course
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 34. Peripheral T-Cell Lymphoma, Not Otherwise Specified
  • Definition
  • SYNONYMS AND RELATED TERMS
  • Epidemiology
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetic and Molecular Characteristics
  • Variants and Subgroups
  • Extranodal Peripheral T-Cell Lymphoma, Not Otherwise Specified
  • Prognosis and Predictive Features
  • Primary Nodal Epstein-Barr Virus–Positive T/Natural Killer–Cell Lymphoma
  • Diagnostic Approach To Peripheral T-Cell Lymphoma, Not Otherwise Specified And Differential Diagnoses
  • Pearls and Pitfalls
  • Chapter 35. Follicular Helper T-Cell Lymphoma
  • Definition
  • Synonyms and Related Terms
  • Epidemiology
  • Etiology
  • Follicular Helper T Cells
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetics
  • Clinical Course and Prognosis
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 36. Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative
  • Definition and Background
  • Anaplastic Large Cell Lymphoma, Alk Positive
  • Anaplastic Large Cell Lymphoma, Alk Negative
  • Breast Implant–Associated Anaplastic Large Cell Lymphoma
  • Differential Diagnosis of Anaplastic Large Cell Lymphoma
  • Pearls and Pitfalls
  • Chapter 37. Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
  • Enteropathy-Associated T-Cell Lymphoma
  • Refractory Celiac Disease
  • Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
  • Intestinal T-Cell Lymphoma, Not Otherwise Specified
  • Indolent Natural Killer–Cell and T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract
  • Pearls and Pitfalls
  • Chapter 38. Mycosis Fungoides and Sézary Syndrome
  • Mycosis Fungoides
  • Sézary Syndrome
  • Pearls and Pitfalls
  • Chapter 39. Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
  • Definition
  • SYNONYMS AND RELATED TERMS
  • Epidemiology
  • Etiology
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Genetics and Molecular Findings
  • Postulated Cell of Origin
  • Clinical Course
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 40. Primary Cutaneous T-Cell Lymphomas: Rare Subtypes
  • Introduction
  • Primary Cutaneous CD8-Positive Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma
  • Primary Cutaneous γδ T-Cell Lymphoma
  • Subcutaneous Panniculitis-Like T-Cell Lymphoma
  • Primary Cutaneous CD4-Positive Small/Medium T-Cell Lymphoproliferative Disorder
  • Primary Cutaneous Acral CD8-Positive T-Cell Lymphoproliferative Disorder
  • Other Types of Cutaneous T-Cell Lymphoma
  • Pearls and Pitfalls
  • Section 3. PRECURSOR B-AND T-CELL NEOPLASMS
  • Chapter 41. Precursor B-Cell and T-Cell Neoplasms
  • Classification of Precursor Lymphoid Neoplasms
  • B-Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
  • T-Cell Lymphoblastic Lymphoma/Lymphoblastic Leukemia
  • Conclusion
  • Pearls and Pitfalls
  • Chapter 42. Acute Leukemias of Ambiguous Lineage
  • Definitions
  • Synonyms and Related Terms
  • Epidemiology
  • Clinical Features
  • Diagnostic Criteria and Lineage Assignment
  • Genetic and Molecular Findings
  • Clinical Course
  • Lineage Switch
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Part IV. Myeloid, Histiocytic, and Related Proliferations
  • Chapter 43. Principles of Classification of Myeloid Neoplasms
  • Introduction
  • Evaluation of Myeloid Neoplasms
  • International Consensus Classification
  • Conclusion
  • Acknowledgment
  • Chapter 44. The Myelodysplastic Syndromes
  • Incidence
  • Synonyms and Related Terms
  • Clinical Features
  • Laboratory Features
  • Diagnosis
  • Classification
  • Differential Diagnosis
  • Etiology and Pathogenesis
  • Conclusion
  • Pearls and Pitfalls
  • Chapter 45. Myeloid and Hematologic Neoplasms With Germline Predisposition
  • Definition and Introduction
  • Synonyms and Related Terms
  • Hematologic Neoplasms with Germline Predisposition Without A Constitutional Disorder Affecting Multiple Organ Systems
  • Hematologic Neoplasms with Germline Predisposition Associated with A Constitutional Platelet Disorder
  • Hematologic Neoplasms with Germline Predisposition Associated with A Constitutional Disorder Affecting Multiple Organ Systems
  • Acute Lymphoblastic Leukemia with Germline Predisposition
  • Pearls and Pitfalls
  • Chapter 46. Acute Myeloid Leukemia
  • SYNONYMS AND RELATED TERMS
  • EPIDEMIOLOGY
  • ETIOLOGY
  • CLINICAL FEATURES
  • MORPHOLOGY
  • CYTOCHEMISTRY
  • IMMUNOPHENOTYPE
  • GENETICS
  • PROGNOSIS
  • ACUTE MYELOID LEUKEMIA DISEASE TYPES
  • MYELOID PROLIFERATIONS OF DOWN SYNDROME
  • MYELOID SARCOMA
  • DIAGNOSTIC QUALIFIERS IN ACUTE MYELOID LEUKEMIA
  • INTEGRATED APPROACH TO THE DIAGNOSIS OF ACUTE MYELOID LEUKEMIA
  • Pearls and Pitfalls
  • Chapter 47. Myeloproliferative Neoplasms
  • Introduction
  • Etiology and Pathogenesis
  • Chronic Myeloid Leukemia (CML)
  • Chronic Neutrophilic Leukemia (CNL)
  • Classic Bcr::Abl1-Negative Myeloproliferative Neoplasms
  • Essential Thrombocythemia (ET)
  • Primary Myelofibrosis (PMF)
  • Polycythemia Vera
  • Chronic Eosinophilic Leukemia, Not Otherwise Specified (CEL, NOS)
  • Myeloproliferative Neoplasms, Unclassifiable (MPN-U)
  • Conclusion
  • Acknowledgments
  • Pearls and Pitfalls
  • Chapter 48. Myelodysplastic/Myeloproliferative Neoplasms and Premalignant Conditions
  • Introduction
  • Chronic Myelomonocytic Leukemia (CMML)
  • Clonal Cytopenia With Monocytosis of Undetermined Significance and Clonal Monocytosis of Undetermined Significance
  • Atypical Chronic Myeloid Leukemia (aCML)
  • Myelodysplastic/Myeloproliferative Neoplasm With Sf3b1 Mutation and Thrombocytosis (MDS/MPN-SF3B1-T)
  • Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis, Not Otherwise Specified (MDS/MPN-RS-T, NOS)
  • Myelodysplastic/Myeloproliferative Neoplasm, Not Otherwise Specified (MDS/MPN, NOS)
  • Myelodysplastic/Myeloproliferative Neoplasm With Isolated Isochromosome (17q) (MDS/MPM With i[17q]; ICC Provisional Subentity)
  • Acknowledgments
  • Pearls and Pitfalls
  • Chapter 49. Mastocytosis
  • Definition
  • Synonyms and Related Terms
  • General Aspects
  • Epidemiology and Etiology
  • Postulated Cell of Origin and Normal Counterpart
  • Genetics and Molecular Findings
  • Cytologic and Histologic Diagnosis
  • Differential Diagnosis
  • Classification
  • Pearls and Pitfalls
  • Chapter 50. Eosinophilia, Chronic Eosinophilic Leukemia, Not Otherwise Specified, and Myeloid/Lymphoid Neoplasms With Eosinophilia and Tyrosine Kinase Gene Fusions
  • Overview
  • Introduction
  • Classification
  • Clinical Presentation
  • Approach To Diagnosis
  • Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangements Of PDGFRA, PDGFRB, FGFR1, FLT3, OR JAK2 or with ETV6::ABL1
  • CEL, NOS, IHE/IHES, and other Rare Reported Genetic Alterations Associated with Clonal Eosinophilia
  • Conclusion
  • Acknowledgments
  • Pearls and Pitfalls
  • Chapter 51. Blastic Plasmacytoid Dendritic Cell Neoplasm
  • Definition
  • Synonyms and Related Terms
  • Epidemiology
  • Etiology
  • Clinical Features
  • Morphology
  • Immunophenotype
  • Cytochemistry
  • Genetics and Molecular Findings
  • Postulated Cell of Origin and Normal Counterpart
  • Clinical Course and Prognosis
  • Differential Diagnosis
  • Pearls and Pitfalls
  • Chapter 52. Histiocytic and Dendritic Cell Proliferations—Systemic and Neoplastic
  • Non-Neoplastic Histiocytic Disorders
  • Histiocytic and Dendritic Cell Neoplasms
  • Acknowledgment
  • Pearls and Pitfalls
  • Part V. Immunodeficiency Disorders
  • Chapter 53. The Pathology of Primary Immunodeficiencies
  • Classification
  • Synonyms and Related Terms
  • Epidemiology
  • Severe Combined Immunodeficiency
  • PI3K-Related Immunodeficiencies
  • Defects that Affect Homeostasis of The Immune System
  • Defects in Synapse Formation and Crosstalk Between Antigen-Presenting Cells and T Cells
  • Pearls and Pitfalls
  • Chapter 54. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
  • Definition
  • Synonyms and Related Terms
  • Classification
  • Posttransplant Lymphoproliferative Disorders
  • Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders in Nontransplant Settings
  • Pearls and Pitfalls
  • Part VI. Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia
  • Chapter 55. Bone Marrow Evaluation for Lymphoma
  • Distinction Between Benign Lymphoid Aggregates and Lymphoma
  • Non-Hodgkin Lymphoma Involving Bone Marrow
  • B-Cell Lymphomas Involving Bone Marrow
  • T-Cell Lymphomas Involving Bone Marrow
  • Hodgkin Lymphoma Involving Bone Marrow
  • Nonlymphoid Malignancies That Mimic Lymphomas
  • Pearls and Pitfalls
  • Chapter 56. Evaluation of the Bone Marrow After Therapy
  • Effects of Selected Therapies and Bone Marrow Transplantation
  • Acute Leukemia or Myelodysplastic Syndrome
  • Chronic Myeloid Leukemia
  • BCR::ABL1-Negative Myeloproliferative Neoplasms
  • Chronic Lymphoproliferative and Plasma Cell Disorders
  • Other Bone Marrow Changes after Therapy
  • Pearls and Pitfalls
  • Chapter 57. Non-hematopoietic Neoplasms and Other Lesions of the Bone Marrow and Lymph Nodes
  • Introduction
  • Metastatic Tumors of the Bone Marrow
  • Primary Tumors of Bone
  • Vascular Tumors Involving Bone
  • Other Soft-Tissue Tumors Involving Bone
  • Malignant Lymphomas Involving Bone and Bone Marrow
  • Benign Lesions of Bone
  • Metastatic Tumors to Lymph Nodes
  • Benign Lymph Node Inclusions
  • Mesenchymal Proliferations in Lymph Nodes
  • Conclusion
  • Pearls and Pitfalls
  • Chapter 58. Spleen: Normal Architecture and Neoplastic and Non-neoplastic Lesions
  • The Normal Spleen
  • Gross Examination
  • Lymphoid Hyperplasia
  • Castleman Disease
  • Autoimmune Lymphoproliferative Syndrome
  • Hodgkin Lymphoma
  • Non-Hodgkin Lymphomas
  • Precursor Lymphoid Neoplasms
  • Systemic or Secondary Mature B-Cell Lymphomas and Leukemias
  • Primary B-Cell Lymphoid Neoplasms Presenting With Prominent Splenomegaly
  • Mature T-Cell and Natural Killer–Cell Neoplasms
  • T-Cell Lymphoid Neoplasms Presenting With Prominent Splenomegaly
  • Myeloid Neoplasms
  • Systemic Mastocytosis
  • Proliferations of the Monocyte-Macrophage System
  • Mesenchymal Tumors and Non-Neoplastic Disorders That Mimic Neoplasms
  • EPSTEIN-BARR VIRUS—POSITIVE INFLAMMATORY FOLLICULAR DENDRITIC CELL/FIBROBLASTIC RETICULAR CELL TUMOR AND REACTIVE PSEUDOTUMORAL LESIONS OF THE SPLEEN
  • Splenic Cysts
  • Other Tumors
  • Storage Diseases
  • Pearls and Pitfalls
  • Chapter 59. Diagnosis of Lymphoma in Extranodal Sites Other Than Skin
  • Lymphomas of Immune-Privileged Sites
  • Lymphoma of The Nervous System and Meninges
  • Ocular Adnexal Lymphoma
  • Lymphomas of Waldeyer’s Ring
  • Lymphomas of The Nasal Cavity and Paranasal Sinuses
  • Salivary Gland Lymphomas
  • Lymphomas of The Oral Cavity
  • Thyroid Lymphomas
  • Laryngeal Lymphomas
  • Pulmonary Lymphomas
  • Lymphomas of The Pleura and Pleural Cavity
  • Lymphomas of The Thymus
  • Cardiac Lymphomas
  • Lymphomas of The Breast
  • Gastrointestinal Lymphomas
  • Gastric Lymphoma
  • Small and Large Intestinal Lymphomas
  • Lymphomas of The Liver and Pancreatobiliary Tract
  • Adrenal Lymphomas
  • Urinary Tract Lymphomas
  • Male Genital Tract Lymphomas
  • Lymphomas of The Female Genital Tract
  • Lymphomas of Bone
  • Pearls and Pitfalls
  • Appendix A. The International Consensus Classification of Myeloid, Lymphoid, and Histiocytic Neoplasms
  • Index