Epigenetic Drug Discovery and the Future of Precision Medicine
Epigenetic drug discovery is reshaping precision medicine. Instead of seeing the genome as a fixed script, researchers now understand that chemical “marks” on DNA and histones can switch genes on or off without changing the DNA sequence itself. These reversible marks are at the heart of epigenetic drug discovery and are opening new possibilities for truly personalised therapies.
In cancer, autoimmune and neurodegenerative diseases, abnormal epigenetic patterns can silence tumour-suppressor genes, activate inflammatory pathways or disrupt neuronal function. By targeting the enzymes and proteins that write, read or erase these marks, epigenetic drugs aim to restore healthy gene expression and improve patient outcomes. Several histone deacetylase (HDAC) inhibitors and DNA methyltransferase (DNMT) inhibitors are already approved, and many more compounds are in clinical development.
Epigenetic Drug Discovery: a new reference
Epigenetic Drug Discovery: Advancements, Challenges, and Applications in Precision Medicine brings this rapidly evolving field together in one comprehensive volume. The book covers:
- Fundamental mechanisms of epigenetic regulation and gene expression
- Disease-specific epigenetic changes in cancer, autoimmune, inflammatory and neurodegenerative disorders
- Biomarkers and multi-omics strategies for patient stratification
- The role of gut microbiota, probiotics and prebiotics in epigenetic healing
- In silico tools, docking studies and AI-enabled approaches for discovering and optimising epigenetic drugs
- Novel delivery systems and personalised treatment pathways
International experts from India, Australia and beyond explore how traditional medicine, marine-derived compounds and natural products can be translated into modern epigenetic therapies. This global perspective is particularly valuable for institutions that serve diverse patient populations and emerging research hubs.
Why this topic matters for libraries and professionals
International initiatives such as the International Human Epigenome Consortium (IHEC) are building high-resolution reference epigenome maps across many cell types. These open datasets are accelerating biomarker discovery and helping researchers understand how environmental exposures and lifestyle factors leave epigenetic “signatures” in tissues.
At the same time, public health agencies highlight how epigenetic changes link behaviours, environment and health outcomes across the lifespan. Epigenetics provides a bridge between genomics, prevention and precision medicine, and it is becoming central to how we design therapies, monitor risk and tailor interventions to individual patients.
For medical schools, pharmacy faculties, hospitals and research institutes, keeping collections up to date in this area is critical. Epigenetic drug discovery touches oncology, immunology, neurology, pharmacology, toxicology and even nutrition and environmental health.
Epigenetic Drug Discovery: Advancements, Challenges, and Applications in Precision Medicine is an ideal reference for:
- Academic and hospital libraries that support translational research
- Pharmaceutical science and pharmacology programmes
- Biotech and biopharma R&D teams working on targeted and personalised therapies
- Clinicians interested in the practical implications of epigenetic biomarkers
CLNZ Books offers this hardback with free worldwide shipping and personalised service for institutions that prefer working with a specialised bookseller rather than a marketplace algorithm.
Useful international links
- International Human Epigenome Consortium (IHEC) – global coordination of reference epigenome mapping initiatives. https://ihec-epigenomes.org/
- National Human Genome Research Institute (NHGRI) – Epigenomics factsheets and resources on epigenetics and genomics. https://www.genome.gov
- Centers for Disease Control and Prevention (CDC) – Genomics and Precision Health resources linking epigenetics, behaviour and disease risk. https://www.cdc.gov/genomics
- European Medicines Agency (EMA) – scientific guidelines and assessment of innovative medicines, including targeted and advanced therapies. https://www.ema.europa.eu
If your library or research group is updating collections in epigenetics, drug discovery or precision medicine, you can order this title and explore related books through the CLNZ Books Medicine Collection.