Beyond Amyloid: Why Brain Metabolism Is Alzheimer's Next Research Frontier
Beyond Amyloid: Why Brain Metabolism Is Alzheimer's Next Research Frontier
For two decades, Alzheimer's research centered on amyloid plaques and tau tangles. That focus is widening. A high-resolution metabolomics study published in Alzheimer's & Dementia (September 2025) profiled 162 human frontal cortex samples and identified 155 distinct metabolic features across 36 biological pathways tied to Alzheimer's neuropathology — evidence that energy metabolism disruption is not a side effect of the disease, but one of its core drivers. Separately, research groups including Stanford's Knight Initiative for Brain Resilience have shown that restoring brain metabolism in animal models can improve memory and cognitive function, opening a genuinely new therapeutic avenue beyond anti-amyloid drugs.
Brain Energy Metabolism in Alzheimer's Disease – Part C (Volume 188 of the International Review of Neurobiology, edited by Subashchandrabose Chinnathambi) arrives at exactly this inflection point. It brings together contributions from an international board of researchers covering mitochondrial dysfunction, insulin resistance in the brain, oxidative stress, and the metabolic pathways now considered central to Alzheimer's pathogenesis — a direct, up-to-date reference for the question the field is currently organizing itself around.
It's a natural complement to the growing Medicine collection at CLNZ Books, alongside our other neuroscience and neurology titles.
Q&A
What role does brain energy metabolism play in Alzheimer's disease?
Growing evidence points to mitochondrial dysfunction and disrupted energy metabolism as early, central features of Alzheimer's pathology — not just downstream consequences of amyloid or tau accumulation.
Is metabolic dysfunction a cause or a consequence of Alzheimer's pathology?
Current research suggests both: metabolic disruption appears early in disease progression and may actively drive further neurodegeneration, making it a candidate target for intervention rather than only a biomarker.
What does "Brain Energy Metabolism in Alzheimer's Disease – Part C" cover?
Volume 188 of the International Review of Neurobiology series brings together international contributions on mitochondrial dysfunction, insulin resistance, oxidative stress, and metabolic pathways implicated in Alzheimer's, continuing the multi-part series from Parts A and B.
Who is this volume written for?
Researchers, clinicians, neurologists, and academic libraries working in neurodegeneration, dementia research, and translational neuroscience.
What is the ISBN, and does CLNZ Books ship internationally?
ISBN 9780443345258. Yes — CLNZ Books ships worldwide, with the price already including shipping. Payment by credit card or PayPal.